An unusual occurrence on attempted purine C-8 electrophilic fluorination of 5'-noraristeromycin.
نویسندگان
چکیده
Reaction of the in situ generated purine C-8 carbanion of a protected 5'-noraristeromycin derivative with N-fluorobenzenesulfonimide gave 8-phenylsulfonyl-5'-noraristeromycin rather than the expected 8-fluoro derivative. A single electron transfer (SET) mechanism is proposed for this occurrence. The phenylsulfonyl product offers a structural feature common to some anti-HIV agents. [reaction: see text]
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ورودعنوان ژورنال:
- Organic letters
دوره 7 18 شماره
صفحات -
تاریخ انتشار 2005